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Luteal support is the administration of medication, generally progesterone, progestins or GnRH agonists, to increase the success rate of implantation and early embryogenesis, thereby complementing and/or supporting the function of the corpus luteum. The live birth rate is significantly higher with progesterone for luteal support in IVF cycles with or without intracytoplasmic sperm injection (ICSI). Co-treatment with GnRH agonists further improves outcomes,〔 by a live birth rate RD of +16% (95% confidence interval +10 to +22%). ==Formulations of progesterone or progestin== The main formulations of progesterone or progestins for luteal support are: *Formulations for intramuscular administrations *Vaginal tablets or other inserts for intravaginal administration, such as endometrin While daily intramuscular injections of progesterone-in-oil (PIO) have been the standard route of administration, PIO injections are not FDA-approved for use in pregnancy. A Cochrane review in 2013 stated that synthetic progesterone appears to be better than micronized progesterone. A Cochrane review in 2011 found no evidence favoring a specific route of administration, dosage or duration of progesterone for luteal support.〔 Progestins used for luteal support include dydrogesterone and 17α-hydroxyprogesterone caproate For egg donation, there is evidence of a lower pregnancy rate and a higher cycle cancellation rate when the progesterone supplementation in the recipient is commenced ''prior'' to oocyte retrieval from the donor, as compared to commenced day of oocyte retrieval or the day after.〔 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「luteal support」の詳細全文を読む スポンサード リンク
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